SS-208
SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma[1].
Product Specifications
CAS Number
[2245942-72-5]
Product Name Alternative
AVS100
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ss-208.html
Purity
99.00
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=NOC(CCNC(C2=CC=C(Cl)C(Cl)=C2)=O)=C1)NO
Molecular Formula
C13H11Cl2N3O4
Molecular Weight
344.15
Precautions
H228, H315, H319
References & Citations
[1]Shen S, et al. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem. 2019 Sep 4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC5; HDAC6; HDAC7; HDAC8
Available Sizes
Curated Selection
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