β-Amyloid (25-35)

β-Amyloid (25-35) (Amyloid beta-peptide (25-35) ) is the fragment Aβ (25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells[1].

Product Specifications

CAS Number

[131602-53-4]

Product Name Alternative

Amyloid beta-peptide (25-35) ; Aβ25-35; β-Amyloid peptide (25-35)

UNSPSC

12352209

Target

Amyloid-β

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Amyloid_beta-peptide_25-35_.html

Purity

99.85

Solubility

H2O : 3.33 mg/mL

Smiles

CSCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](C)NC(CNC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CO)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C45H81N13O14S

Molecular Weight

1060.27

References & Citations

[1]D'Ursi AM, et al. Solution structure of amyloid beta-peptide (25-35) in different media. J Med Chem. 2004 Aug 12;47 (17) :4231-8.|[2]Clementi ME, et al. Abeta (31-35) and Abeta (25-35) fragments of amyloid beta-protein induce cellular death throughapoptotic signals: Role of the redox state of methionine-35. FEBS Lett. 2005 May 23;579 (13) :2913-8.|[3]Liu M, et al. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease. BMC Complement Altern Med. 2015 Oct 23;15:382.|[4]Patel NS, et al. Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide. Amyloid. 2008;15 (1) :5-19.|[5]Julia Fedotova, et al. Ropren® is a polyprenol preparation from coniferous plants that ameliorates cognitive deficiency in a rat model of beta-amyloid peptide- (25–35) -induced amnesia. Phytomedicine. 2012 Mar 15;19 (5) :451-6.