Ac-Tyr (PO3H2) -Glu-Glu-Ile-Glu-OH
Ac-Tyr (PO3H2) -Glu-Glu-Ile-Glu-OH (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM) . Ac-Tyr (PO3H2) -Glu-Glu-Ile-Glu-OH is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].
Product Specifications
CAS Number
159439-02-8
UNSPSC
12352209
Target
Src
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-tyr-po3h2-glu-glu-ile-glu-oh.html
Solubility
H2O
Smiles
O=C(O)CC[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)=O)=O)=O)=O
Molecular Formula
C32H46N5O17P
Molecular Weight
803.70
References & Citations
[1]G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41 (11) :1894-908.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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