AZ14170133

AZ14170133 (SG 3932) is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. AZ14170133 can be used to synthesis antibody-drug conjugate (ADC) [1].

Product Specifications

CAS Number

[2495742-34-0]

Product Name Alternative

SG 3932; AZ-0133

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mal-peg8-amide-val-ala-4-nh2-exatecan.html

Purity

99.73

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN6C(C=CC6=O)=O)=O)=O)=O)=O)=CC7=C1COC([C@]7(O)CC)=O

Molecular Formula

C57H77N7O18

Molecular Weight

1148.26

References & Citations

[1]Philip Wilson Howard, et al. Compounds and conjugates thereof. Patent US20200306243A1.|[2]Schmidt, et al. Computer-based scoring method indicating a cancer patient's response to an anti-B7H4 antibody-drug conjugate therapy using a convolutional neural network, WO2022053685, 2022.