Protopine (hydrochloride)
Product Specifications
UNSPSC Description
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
Target Antigen
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protopine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1CC2=C(CN(CCC3=CC4=C(C=C31)OCO4)C)C5=C(C=C2)OCO5.Cl
Molecular Weight
389.83
References & Citations
[1]Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65(3):218-21. |[2]Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21(1):396.|[3]Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun;50(8):934-40. |[4]Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):85-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0793A/Protopine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0793A/
Clinical Information
No Development Reported
CAS Number
6164-47-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1055975-01 0.02 mg (E-Coli)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details MBS1055975-02 0.1 mg (E-Coli)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details 
MBS1055975-03 0.02 mg (Yeast)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details 
MBS1055975-04 0.1 mg (Yeast)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details MBS1055975-05 0.02 mg (Baculovirus)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details MBS1055975-06 0.02 mg (Mammalian-Cell)
Recombinant Escherichia coli O139:H28 Purine nucleoside phosphorylase DeoD-type (deoD)
Ask
View Details