PSMA Mouse Monoclonal Antibody [A9H10]
Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-L-aspartyl-L-glutamate peptidase I (NAALADase I), NAAG peptidase, or prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene. Human GCPII contains 750 amino acids and weighs approximately 84 kDa. GCPII is a zinc metalloenzyme that resides in membranes. Most of the enzyme resides in the extracellular space. GCPII is a class II membrane glycoprotein. It catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA) according to the reaction scheme to the right. Neuroscientists primarily use the term NAALADase in their studies, while those studying folate metabolism use folate hydrolase, and those studying prostate cancer or oncology, PSMA. All refer to the same protein glutamate carboxypeptidase II.
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
FOLH1, FOLH, NAALAD1, PSM, PSMA
Swiss Prot
Q04609 Human
Cellular Locus
Cell membrane, Cytoplasm.
Host
Mouse
Species Reactivity
Human
Immunogen
Recombinant protein within human PSMA aa 20-750 / 750.
Isotype
IgG2b
Clone
A9H10
Conjugation
Non-conjugated
Type
Mouse monoclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
LNCaP cell lysate, 22RV1 cell lysate, human prostate tissue, human prostate carcinoma tissue, LNCaP.
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:100
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 84 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
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