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C2 L-threo Ceramide (d18:1/2:0)

C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer (d18:1/2:0) ; L-threo Ceramide (d18:1/2:0) ) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.

Product Specifications

CAS Number

[143615-69-4]

Product Name Alternative

L-threo Cer (d18:1/2:0) ; L-threo Ceramide (d18:1/2:0) ; N-acetyl-L-threo-Sphingosine

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/c2-l-threo-ceramide-d18-1-2-0.html

Smiles

CC(N[C@H]([C@H](/C=C/CCCCCCCCCCCCC)O)CO)=O

Molecular Formula

C20H39NO3

Molecular Weight

341.53

References & Citations

[1]Park, et al. Inhibitory activity of a ceramide library in interleukin-4 production from activated T cells. Bioorg. Med. Chem. 13 (7), 2589-2595 (2005) .

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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