Schisantherin D

Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects[1][2].

Product Specifications

CAS Number

[64917-82-4]

UNSPSC

12352005

Target

HIV

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/schisantherin-d.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(C([C@@H]([C@@](O)2C)OC(C3=CC=CC=C3)=O)=CC4=C1OCO4)C(C(C[C@@H]2C)=CC5=C6OCO5)=C6OC

Molecular Formula

C29H28O9

Molecular Weight

520.53

References & Citations

[1]D F Chen, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59 (11) :1066-8.|[2]Jin-Biao Xu, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020 Aug 10;258:112813.