RG14620
RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
Product Specifications
CAS Number
136831-49-7
Product Name Alternative
Tyrphostin RG14620
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RG14620.html
Concentration
10mM
Purity
98.09
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CC=CN=C1)=C/C2=CC(Cl)=CC(Cl)=C2
Molecular Formula
C14H8Cl2N2
Molecular Weight
275.13
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sagara Y, et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem. 2002 Sep 27;277 (39) :36204-15.|[2]Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51 (16) :4430-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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