PF-1163A
PF-1163A is an antifungal agent that inhibits Ergosterol synthesis (IC50 = 12 ng/mL), which is found in a fermentation broth of Penicillium sp. PF-1163A also inhibits C-4 sterol methyl oxidase with an MIC value of 12.5 µg/mL[1][2].
Product Specifications
CAS Number
258871-59-9
UNSPSC
12352005
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pf-1163a.html
Smiles
O=C(O[C@@H](CC[C@@H](CCCCC(N1C)=O)C)C[C@@H](O)CCC)[C@@H]1CC2=CC=C(C=C2)OCCO
Molecular Formula
C27H43NO6
Molecular Weight
477.63
References & Citations
[1]Nose H, et al. PF1163A, a novel antifungal agent, inhibit ergosterol biosynthesis at C-4 sterol methyl oxidase. J Antibiot (Tokyo) . 2002 Nov;55 (11) :969-74.|[2]Okabe M, et al. Macrolides from a Marine-Derived Fungus, Penicillium meleagrinum var. viridiflavum, Showing Synergistic Effects with Fluconazole against Azole-Resistant Candida albicans. J Nat Prod. 2016 Apr 22;79 (4) :1208-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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