Ferroptosis-IN-8

Ferroptosis-IN-8 is a potent ferroptosis inhibitor with an EC50 of 40.49 nM. Ferroptosis-IN-8 effectively reduces lipid ROS levels in cells. Ferroptosis-IN-8 act as an antioxidant by capturing lipid radicals, leading to a reduction in the accumulation of harmful lipid peroxides and, ultimately, inhibiting ferroptosis[1].

Product Specifications

CAS Number

[3056016-82-8]

UNSPSC

12352005

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ferroptosis-in-8.html

Purity

98.24

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=C(C=CC=C1O)C(N/N=C/C2=CC=C(C=C2)OC)=O

Molecular Formula

C15H15N3O3

Molecular Weight

285.30

References & Citations

[1]Sheng xiehua, et al. Discovery of Novel Ortho-Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activitie. J. Med. Chem. 2024; 67: 9536−9551.