U0124

U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].

Product Specifications

CAS Number

[108923-79-1]

UNSPSC

12352211

Hazard Statement

H301, H315, H319, H335

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/u0124.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC(/C(C#N)=C(N)/SC)=C(N)\SC

Molecular Formula

C8H10N4S2

Molecular Weight

226.32

Precautions

H301, H315, H319, H335

References & Citations

[1]M F Favata, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273 (29) :18623-32.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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