U0124
U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].
Product Specifications
CAS Number
[108923-79-1]
UNSPSC
12352211
Hazard Statement
H301, H315, H319, H335
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/u0124.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC(/C(C#N)=C(N)/SC)=C(N)\SC
Molecular Formula
C8H10N4S2
Molecular Weight
226.32
Precautions
H301, H315, H319, H335
References & Citations
[1]M F Favata, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273 (29) :18623-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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