AZD5597

AZD5597 is an inhibitor of CDK with IC50 values of both 2 nM for CDK1 and CDK2. AZD5597 can inhibit the proliferation of tumor cells and has anti-tumor activity[1].

Product Specifications

CAS Number

[924641-59-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azd5597.html

Purity

98.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1C(C2=NC(NC3=CC=C(C=C3)C(N4C[C@H](CC4)NC)=O)=NC=C2F)=CN=C1C)C

Molecular Formula

C23H28FN7O

Molecular Weight

437.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Jones CD, et al.The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett. 2008 Dec 15;18 (24) :6369-73.