AZD5597
AZD5597 is an inhibitor of CDK with IC50 values of both 2 nM for CDK1 and CDK2. AZD5597 can inhibit the proliferation of tumor cells and has anti-tumor activity[1].
Product Specifications
CAS Number
924641-59-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/azd5597.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(N1C(C2=NC(NC3=CC=C(C=C3)C(N4C[C@H](CC4)NC)=O)=NC=C2F)=CN=C1C)C
Molecular Formula
C23H28FN7O
Molecular Weight
437.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Jones CD, et al.The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett. 2008 Dec 15;18 (24) :6369-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2
Available Sizes
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