GFRα2/3-IN-1
GFRα2/3-IN-1 (Compound 16) is a selective GFRα2/3 inhibitor with IC50 values of 0.1 and 0.2 μM for GFRα2 and GFRα3, respectively. GFRα2 is a glial cell line-derived neurotrophic factor (GDNF) receptor related to GFRα1, GFRα2/3-IN-1 can be used for pain and itch research[1].
Product Specifications
UNSPSC
12352005
Target
GDNF Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gfrα2-3-in-1.html
Smiles
CNC([C@@H](C1CCCCC1)NC(CC2=CC(O[C@@H]3CC4=C(C3)C=C(C=C4)C5=CN=C(N=C5)NC6=CC=CC=C6)=CC=C2)=O)=O
Molecular Formula
C36H39N5O3
Molecular Weight
589.73
References & Citations
[1]Johnson SL, et al. Discovery of the first selective, small-molecule GFRα2/3 inhibitors through DNA-encoded library technology. Bioorg Med Chem Lett. 2024 Sep 15;110:129889.|[2]Jing S, et al. GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. J Biol Chem. 1997 Dec 26;272 (52) :33111-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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