Ex26
Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM) . Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].
Product Specifications
CAS Number
1233332-37-0
Product Name Alternative
S1P1-IN-Ex26
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ex26.html
Purity
99.4
Solubility
10 mM in DMSO
Smiles
O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O
Molecular Formula
C28H28ClFN2O3
Molecular Weight
494.98
References & Citations
[1]Stuart M Cahalan, et al. Sphingosine 1-phosphate receptor 1 (S1P (1) ) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P (1) antagonist. Mol Pharmacol. 2013 Feb;83 (2) :316-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
475914 100 µL
ATP5A1 (ATP Synthase Subunit Alpha, Mitochondrial, ATP Synthase, H+ Transporting, Mitochondrial F1 Complex, Alpha Subunit 1, Cardiac Muscle)
Sign In for Pricing
View Details 
GTR15368741 1 Vial
Lentiviral human CST4 sgRNA gene knockout kit - Lentiviral human CST4 sgRNA gene knockout kit (plasmid)
Sign In for Pricing
View Details 