Sofpironium (bromide)
Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH) . Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes[1].
Product Specifications
CAS Number
[1628106-94-4]
Product Name Alternative
BBI 4000
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sofpironium-bromide.html
Concentration
10mM
Purity
98.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC(C[N+](C)(CC1)C[C@@H]1OC([C@@](C2CCCC2)(C3=CC=CC=C3)O)=O)=O.[Br-]
Molecular Formula
C22H32BrNO5
Molecular Weight
470.40
References & Citations
[1]Julia Paik, et al. Sofpironium Bromide: First Approval. Drugs. 2020 Dec;80 (18) :1981-1986.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAChR3; mAChR4; mAChR5
Available Sizes
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