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Amorfrutin A

Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis[1].

Product Specifications

CAS Number

80489-90-3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amorfrutin-a.html

Smiles

O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)\C)=C1O

Molecular Formula

C21H24O4

Molecular Weight

340.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shi H, et al., Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products. Int Immunopharmacol. 2014 Jul;21 (1) :56-62.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Frequently Asked Questions

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