Amorfrutin A
Amorfrutin A is the inhibition of NF-κB activation, that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity. Amorfrutin A promotes TNF-α-induced apoptosis in HeLa cell through promotion of caspase-3 and PARP proteolysis[1].
Product Specifications
CAS Number
80489-90-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amorfrutin-a.html
Smiles
O=C(O)C1=C(CCC2=CC=CC=C2)C=C(OC)C(C/C=C(C)\C)=C1O
Molecular Formula
C21H24O4
Molecular Weight
340.41
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Shi H, et al., Amorfrutin A inhibits TNF-α-induced NF-κB activation and NF-κB-regulated target gene products. Int Immunopharmacol. 2014 Jul;21 (1) :56-62.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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