Keap1-Nrf2-IN-23
Keap1-Nrf2-IN-23 (compound 56) is an inhibitor of the Keap1-Nrf2 PPI (IC50=16.0 nM) . Keap1-Nrf2-IN-23 binds to Keap1 with a Kd value of 3.07 nM. Keap1-Nrf2-IN-23 has oral activity[1].
Product Specifications
CAS Number
2771115-65-0
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-23.html
Smiles
O=C(N1CC2=CC=CC(C(CC(O)=O)C3=CC(OC)=C(N(C)N=N4)C4=C3)=C2CC1)C5=C(Cl)C=C(OC(C)C)C=C5
Molecular Formula
C30H31ClN4O5
Molecular Weight
563.04
References & Citations
[1]Zeyu Shi, et al. Discovery of Propionic Acid Derivatives with a 5-THIQ Core as Potent and Orally Bioavailable Keap1-Nrf2 Protein-Protein Interaction Inhibitors for Acute Kidney Injury. J Med Chem. 2024 Oct 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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