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Keap1-Nrf2-IN-23

Keap1-Nrf2-IN-23 (compound 56) is an inhibitor of the Keap1-Nrf2 PPI (IC50=16.0 nM) . Keap1-Nrf2-IN-23 binds to Keap1 with a Kd value of 3.07 nM. Keap1-Nrf2-IN-23 has oral activity[1].

Product Specifications

CAS Number

2771115-65-0

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/keap1-nrf2-in-23.html

Smiles

O=C(N1CC2=CC=CC(C(CC(O)=O)C3=CC(OC)=C(N(C)N=N4)C4=C3)=C2CC1)C5=C(Cl)C=C(OC(C)C)C=C5

Molecular Formula

C30H31ClN4O5

Molecular Weight

563.04

References & Citations

[1]Zeyu Shi, et al. Discovery of Propionic Acid Derivatives with a 5-THIQ Core as Potent and Orally Bioavailable Keap1-Nrf2 Protein-Protein Interaction Inhibitors for Acute Kidney Injury. J Med Chem. 2024 Oct 10.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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