Kazinol B

Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2].

Product Specifications

CAS Number

[99624-27-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Akt; AMPK; NO Synthase

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/kazinol-b.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C/CC1=C([C@H]2OC3=CC(O)=CC=C3CC2)C=C4C(OC(C)(C)C=C4)=C1O

Molecular Formula

C25H28O4

Molecular Weight

392.49

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6.|[2]Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74 (4) :350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki.