Trichostatin A
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1].
Product Specifications
CAS Number
58880-19-6
Product Name Alternative
TSA
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC; Organoid
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Trichostatin-A.html
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic) |Methanol : 2 mg/mL (ultrasonic)
Smiles
CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C
Molecular Formula
C17H22N2O3
Molecular Weight
302.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7 (4) :971-6.|[2]Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A., Reprod Sci. 2012 Aug 8.|[3]Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner., Stem Cells Dev. 2012 Aug 8.|[4]Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20 (6) :538-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HDAC
Available Sizes
Frequently Asked Questions
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