Trichostatin A

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1].

Product Specifications

CAS Number

[58880-19-6]

Product Name Alternative

TSA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HDAC; Organoid

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Trichostatin-A.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic) |Methanol : 2 mg/mL (ultrasonic)

Smiles

CN(C1=CC=C(C=C1)C([C@@H](/C=C(/C=C/C(NO)=O)C)C)=O)C

Molecular Formula

C17H22N2O3

Molecular Weight

302.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Vigushin DM et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 2001 Apr;7 (4) :971-6.|[2]Karolczak-Bayatti M, et al. Expression of the GTP-Binding Protein Gαs in Human Myometrial Cells is Regulated by Ubiquitination and Protein Degradation: Involvement of Proteasomal Inhibition by Trichostatin A., Reprod Sci. 2012 Aug 8.|[3]Hu X, et al. Histone deacetylase inhibitor trichostatin A promotes the osteogenic differentiation of rat adipose-derived stem cells by altering the epigenetic modifications on Runx2 promoter in a BMP signaling-dependent manner., Stem Cells Dev. 2012 Aug 8.|[4]Azechi T, et al. Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase. J Atheroscler Thromb. 2013;20 (6) :538-47.