Melflufen (hydrochloride)
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3].
Product Specifications
CAS Number
380449-54-7
Product Name Alternative
Melphalan flufenamide (hydrochloride)
UNSPSC
12352005
Hazard Statement
H300, H315, H340, H350, H361
Target
Apoptosis; DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/melflufen-hydrochloride.html
Purity
98.06
Solubility
DMSO : 33.33 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)
Smiles
O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O.[H]Cl
Molecular Formula
C24H31Cl3FN3O3
Molecular Weight
534.88
Precautions
H300, H315, H340, H350, H361
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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