Melflufen (hydrochloride)

Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3].

Product Specifications

CAS Number

[380449-54-7]

Product Name Alternative

Melphalan flufenamide (hydrochloride)

UNSPSC

12352005

Hazard Statement

H300, H315, H340, H350, H361

Target

Apoptosis; DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/melflufen-hydrochloride.html

Purity

98.06

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic)

Smiles

O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O.[H]Cl

Molecular Formula

C24H31Cl3FN3O3

Molecular Weight

534.88

Precautions

H300, H315, H340, H350, H361

References & Citations

[1]Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19 (11) :3019-3031.|[2]Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174 (3) :397-409.|[3]McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18 (1) :52.