REM127
REM127 is a small molecule compound capable of modulating calcium homeostasis in cells and possesses neuroprotective effects. REM127 can restore the calcium homeostasis imbalance in cellular models caused by pathological accumulation of tau protein. REM127 can efficiently cross the blood-brain barrier, and it has the potential to rescue synaptic and cognitive deficits in Alzheimer's disease animal models, as well as to slow down the progression of amyloid-beta and tau protein pathologies. REM127 can be used for research in neurodegenerative diseases[1].
Product Specifications
CAS Number
1417823-67-6
UNSPSC
12352005
Target
Amyloid-β; Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rem127.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
ClC1=C(CCN2CCN(C3=NC(C4=CC=C(Cl)C=C4)=NS3)CC2)C=CC=C1
Molecular Formula
C20H20Cl2N4S
Molecular Weight
419.37
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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