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Anti-ICAD (NT) Antibody

Rabbit Polyclonal Antibody specific to ICAD (NT)

Product Specifications

Product Name Alternative

DNA fragmentation factor 45 kDa subunit, DFF-45, Inhibitor of CAD, ICAD

Gene Name

Dffa

Gene ID

13347

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=Dffa">Dffa</a>

UniProt

O54786

Accession Number

NP_001020467

Cellular Locus

Cytoplasm

Host

Rabbit

Reactivity

Mouse

Immunogen

Peptide corresponding to aa 2-21 at the N-terminus of mouse ICAD (accession no. O54786).

Target Antigen

DNA fragmentation factor subunit α

Target

ICAD (NT)

Clonality

Polyclonal

Isotype

IgG

Type

Antibody

Applications

ELISA, WB, IHC-P, IF

Field of Research

Apoptosis

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Inhibitor of the caspase-activated DNase (DFF40).

Additionnal Information

Immunoblotting : use at 1ug/mL. <br><br>Immunohistochemistry: use at 2ug/mL. <br><br>Positive control: Mouse lung tissue lysate. <br><br>These are recommended concentrations. <br><br>Enduser should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Product Datasheet

https://www.qedbio.com/wp-content/uploads/pdf/2425.pdf

Specificity

This antibody recognizes non-cleaved (45kDa) and cleaved mouse ICAD.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

A human DNA fragmentation factor (DFF) that is cleaved by caspase-3 during apoptosis was identified recently. The mouse homologue of human DFF was identified as a DNase inhibitor and was designated ICAD (inhibitor of caspase- activated DNase). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in nuclei. Therefore, cleavage of CAD inhibitor molecule DFF/ICAD, which causes DNase activation and DNA degradation, is a hallmark of apoptotic cell death.

CAS Number

9007-83-4

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