SCH28080
SCH28080 is a reversible, K+-competitive inhibitor of the gastric H, K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity[1][2][3].
Product Specifications
CAS Number
76081-98-6
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Proton Pump
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/sch28080.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CCC1=C(C)N=C2C(OCC3=CC=CC=C3)=CC=CN21
Molecular Formula
C17H15N3O
Molecular Weight
277.32
Precautions
H302, H312, H332
References & Citations
[1]Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+) -ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36 (1) :97-104.|[2]Martin Jakab, et al. The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells. Cell Physiol Biochem. 2017;43 (3) :1037-1051.|[3]Y Hamagishi, et al. Inhibitory Effects of Copiamycin A, a Macrocyclic Lactone Antibiotic, on Gastric H+, K (+) -ATPase, Acid Secretion and Ulcer Formation. Jpn J Pharmacol. 1991 Feb;55 (2) :283-6.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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