SCH28080

SCH28080 is a reversible, K+-competitive inhibitor of the gastric H, K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity[1][2][3].

Product Specifications

CAS Number

[76081-98-6]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/sch28080.html

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CCC1=C(C)N=C2C(OCC3=CC=CC=C3)=CC=CN21

Molecular Formula

C17H15N3O

Molecular Weight

277.32

Precautions

H302, H312, H332

References & Citations

[1]Scott CK, et al. Studies on the mechanism of action of the gastric microsomal (H+ + K+) -ATPase inhibitors SCH 32651 and SCH 28080. Biochem Pharmacol. 1987 Jan 1;36 (1) :97-104.|[2]Martin Jakab, et al. The H+/K+ ATPase Inhibitor SCH-28080 Inhibits Insulin Secretion and Induces Cell Death in INS-1E Rat Insulinoma Cells. Cell Physiol Biochem. 2017;43 (3) :1037-1051.|[3]Y Hamagishi, et al. Inhibitory Effects of Copiamycin A, a Macrocyclic Lactone Antibiotic, on Gastric H+, K (+) -ATPase, Acid Secretion and Ulcer Formation. Jpn J Pharmacol. 1991 Feb;55 (2) :283-6.