Zoliflodacin

Zoliflodacin (ETX0914; AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.

Product Specifications

CAS Number

[1620458-09-4]

Product Name Alternative

ETX0914; AZD0914

UNSPSC

12352005

Target

Antibiotic; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Zoliflodacin.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 140 mg/mL (ultrasonic)

Smiles

O=C(NC(C12[C@]([C@H](C)O[C@H](C)C3)([H])N3C4=C(C=C5C(ON=C5N6C(OC[C@@H]6C)=O)=C4F)C2)=O)NC1=O

Molecular Formula

C22H22FN5O7

Molecular Weight

487.44

References & Citations

[1]Huband MD, et al. In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria. Antimicrob Agents Chemother. 2015 Jan;59 (1) :467-74.