FRETS-VWF73

<strong>FRETS-VWF73</strong> <strong>Catalog number:</strong> MDP0269 <strong>CAS Number: </strong>55508-42-4 <strong>Sequence: </strong>Asp-Arg-Glu-A2pr(Nma)-Ala-Pro-Asn-Leu-Val-Tyr-Met-Val-Thr-Gly-A2pr(Dnp)-Pro-Ala-Ser-Asp-Glu-Ile-Lys-Arg-Leu-Pro-Gly-Asp-Ile-Gln-Val-Val-Pro-Ile-Gly-Val-Gly-Pro-Asn-Ala-Asn-Val-Gln-Glu-Leu-Glu-Arg-Ile-Gly-Trp-Pro-Asn-Ala-Pro-Ile-Leu-Ile-Gln-Asp-Phe-Glu-Thr-Leu-Pro-Arg-Glu-Ala-Pro-Asp-Leu-Val-Leu-Gln-Arg A2pr(Nma): Nβ-[2-(Methylamino)benzoyl]-2,3-diaminopropionic acid A2pr(Dnp): Nβ-(2,4-Dinitrophenyl)-2,3-diaminopropionic acid <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 8314 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Mancini I, Valsecchi C, Lotta LA, Deforche L, Pontiggia S, Bajetta M, Palla R, Vanhoorelbeke K, Peyvandi F. FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients Thromb Haemost. 2014 Aug;112(2):297-303. 2: Kokame K, Nobe Y, Kokubo Y, Okayama A, Miyata T. FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay Br J Haematol. 2005 Apr;129(1):93-100. 3: Groot E, Hulstein JJ, Rison CN, de Groot PG, Fijnheer R. FRETS-VWF73: a rapid and predictive tool for thrombotic thrombocytopenic purpura J Thromb Haemost. 2006 Mar;4(3):698-9. 4: Joly B, Stepanian A, Hajage D, Thouzeau S, Capdenat S, Coppo P, Veyradier A. Evaluation of a chromogenic commercial assay using VWF-73 peptide for ADAMTS13 activity measurement Thromb Res. 2014 Nov;134(5):1074-80. 5: Nowak AA, O'Brien HER, Henne P, Doerr A, Vanhoorelbeke K, Laffan MA, McKinnon TAJ. ADAMTS-13 glycans and conformation-dependent activity J Thromb Haemost. 2017 Jun;15(6):1155-1166. 6: Kremer Hovinga JA, Mottini M, Lämmle B. Measurement of ADAMTS-13 activity in plasma by the FRETS-VWF73 assay: comparison with other assay methods J Thromb Haemost. 2006 May;4(5):1146-8. 7: Mahdian R, Rayes J, Girma JP, Houllier A, Obert B, Meyer D, Veyradier A. Comparison of FRETS-VWF73 to full-length VWF as a substrate for ADAMTS13 activity measurement in human plasma samples Thromb Haemost. 2006 Jun;95(6):1049-51. 8: Eckmann CM, De Laaf RT, Van Keulen JM, Van Mourik JA, De Laat B. Bilirubin oxidase as a solution for the interference of hyperbilirubinemia with ADAMTS-13 activity measurement by FRETS-VWF73 assay J Thromb Haemost. 2007 Jun;5(6):1330-1. 9: Di Stasio E, Lancellotti S, Peyvandi F, Palla R, Mannucci PM, De Cristofaro R. Mechanistic studies on ADAMTS13 catalysis Biophys J. 2008 Sep;95(5):2450-61. <a href="https://pubmed.ncbi.nlm.nih.gov/29534248">10: Clark CC, Mebius MM, de Maat S, Tielens AGM, de Groot PG, Urbanus RT, Fijnheer R, Hazenberg BPC, van Hellemond JJ, Maas C. Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma Thromb Haemost. 2018 Mar;118(3):471-479. </a> <br><strong>Products Related to FRETS-VWF73 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>