AB-161
Product Specifications
UNSPSC Description
AB-161 is an orally active HBV RNA destabilizer and a PAPD5/7 inhibitor, with its primary action focused in the liver. AB-161 treats Hepatitis B Virus (HBV) infection by lowering the levels of Hepatitis B surface antigen (HBsAg), with an EC50 value of 2.2 nM for HBsAg. AB-161 can be used in the field of HBV infection research[1].
Target Antigen
HBV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ab-161.html
Smiles
O=C(O)C1=CC2=C(C3=C(C[C@H]2C(C)(C)C)N4C(C(OC(F)F)=CC(OC)=C4)=N3)NC1=O
Molecular Weight
433.41
References & Citations
[1]Gotchev D, et al. Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-h]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer. J Med Chem. 2024 Nov 28;67(22):20467-20494.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159987/AB-161-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159987/
Clinical Information
No Development Reported
CAS Number
2848560-66-5
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