HDAC-IN-75
HDAC-IN-75 (5d) is a HDAC inhibitor, with IC50 values of 6.32 nM and 1352 nM for HDAC6 and HDAC1, respectively. HDAC-IN-75 (5d) promotes vision rescue in the atp6v0e1–/– zebrafish model of photoreceptor dysfunction[1].
Product Specifications
UNSPSC
12352211
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac-in-75.html
Smiles
O=C(C1=CC=C(C=C1)CNC(N2CC(C3=CC=CC=C3N4CC5=CC=CC=C5)=C4CC2)=O)NO
Molecular Formula
C27H26N4O3
Molecular Weight
454.52
References & Citations
[1]Gabriele Carullo, et al. Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy. J Med Chem. 2024 Jul 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6
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