PHA-680626
PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib -resistant chronic myeloid leukemia cell lines and primary CD34+ cells[1].
Product Specifications
CAS Number
398493-74-8
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; Bcr-Abl; c-Myc; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pha-680626.html
Smiles
O=C(NC1=NNC2=C1CN(C(CC3=CC=CS3)=O)C2)C4=CC=C(N5CCN(C)CC5)C=C4
Molecular Formula
C23H26N6O2S
Molecular Weight
450.56
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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