Farnesyl thiosalicylic acid amide

Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754) . Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer[1].

Product Specifications

CAS Number

[1092521-74-8]

Product Name Alternative

FTS amide; Salirasib amide

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/farnesyl-thiosalicylic-acid-amide.html

Solubility

10 mM in DMSO

Smiles

C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC1=C(C=CC=C1)C(N)=O

Molecular Formula

C22H31NOS

Molecular Weight

357.55

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Goldberg L, et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models. J Med Chem. 2009 Jan 8;52 (1) :197-205.