Isocycloseram
Product Specifications
CAS Number
2061933-85-3
UNSPSC Description
Isocycloseram is an isoxazoline insecticide and acaricide widely recognized as an allosteric modulator of GABA-gated chloride channels. Isocycloseram is active against Lepidopteran, Hemiptera, Coleoptera, Thysanoptera and Diptera pests. Isocycloseram targets the invertebrate Rdl GABA receptor, but the G335M mutation in the third transmembrane domain of the Rdl GABA receptor may mediate resistance[1].
Target Antigen
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/isocycloseram.html
Smiles
O=C(C1=C(C)C=C(C2=NOC(C2)(C(F)(F)F)C3=CC(Cl)=C(C(Cl)=C3)F)C=C1)NC4C(N(CC)OC4)=O
Molecular Weight
548.31
References & Citations
[1]Blythe J, et al. The mode of action of isocycloseram: A novel isoxazoline insecticide. Pestic Biochem Physiol. 2022 Oct;187:105217.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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