Z-VEID-FMK

Z-VEID-FMK (Z-VE (OMe) ID (OMe) -FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis[1][2].

Product Specifications

CAS Number

[210344-96-0]

Product Name Alternative

Z-VE (OMe) ID (OMe) -FMK

UNSPSC

12352209

Target

Apoptosis; Caspase

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-veid-fmk.html

Purity

95.0

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](CCC(OC)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(CF)=O)CC(OC)=O)=O)=O)=O

Molecular Formula

C31H45FN4O10

Molecular Weight

652.71

References & Citations

[1]S-T Lee, et al. Apoptotic insults to human HepG2 cells induced by S- (+) -ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway. Br J Anaesth. 2009 Jan;102 (1) :80-9. |[2]Philippe P Monnier, et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J Neurosci. 2011 Jul 20;31 (29) :10494-505.