Anti-TERE1 Antibody

Rabbit Polyclonal Antibody specific to TERE1

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 2.5.1.-, Transitional epithelial response protein 1

Gene Name

UBIAD1

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=UBIAD1">UBIAD1</a>

UniProt

Q9Y5Z9

Cellular Locus

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Mitochondrion membrane. Cytoplasm. Nucleus.

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids 32-45 of human TERE1. This sequence is 85

Target Antigen

UbiA prenyltransferase domain-containing protein 1

Target

TERE1

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Cancer research

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {PubMed:20953171, PubMed:23374346}.

Additionnal Information

Immunoblotting : use at 1-5ug/ml. A band of approximately 37 kDa is detected. <br><br>These are recommended concentrations. User should determine optimal concentrations for their applications.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes human TERE1. Other species have not been tested.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

A ubiquitously expressed gene designated TERE1 (Transitional Epithelial Response Gene 1), which maps to chromosome 1p36.11-1p36.33, has a significant effect on growth regulation of bladder cancer and may play an equally significant role in growth regulation of prostate cancer. The TERE1 gene is located between the micro- satellite markers D1S2667 and D1S434, a chromosome locus that has been identified as a site of a tumor suppressor gene or genes for multiple tumor types. Induced TERE1 expression in two prostate carcinoma cell lines, LNCaP and PC-3, decreased proliferation up to 80% with a significant increase in the number of cells in G1. The TERE1 transcript is present in most normal human tissues, but is reduced or absent in the majority of muscle invasive TCC (Transitional Cell Carcinoma of the bladder) tumors.