Recombinant Human CCL14
Recombinant human CCL14
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
rHuCCL14, HCC-1
Gene Name
CCL14
UniProt
Q16627
Cellular Locus
Secreted.
Reactivity
Human
Target Antigen
C-C motif chemokine 14
Target
CCL14
Type
Protein
Applications
Migration assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
Has weak activities on human monocytes and acts via receptors that also rPubMed:11085751}.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.Migration Assay in cells expressing CCR1.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.
Specificity
CCL14
Target Background
CCL14, also known as Hemofiltrate CC Chemokine-1 (HCC-1) is a small cytokine (~8kDa) that is constitutively expressed in multiple tissues. Upon processing of the N-terminal residues of full- length HCC-1 by the uPA-plasmin system, the active form of HCC-1 is a strong agonist for CCR1, CCR5, and, to a lesser extent, CCR3. CCL14 causes chemotaxis of different types of leukocytes, and its active form is a potent inhibitor of HIV entry.
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