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CCT070535

CCT070535 blocks TCF-dependent transcription at the TCF level, with GI50 values of 17.6 μM, 11.1 μM, 11.8 μM and 13.4 μM in HT29 (APC mutant), HCT116 (oncogenic β-catenin), SW480 (APC mutant) and SNU475 (Axin mutant) cells, respectively[1].

Product Specifications

CAS Number

485319-41-3

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cct070535.html

Smiles

O=C1C(CC2=CC=CC=C2)=C([O-])[N+]3=NC(Cl)=CC=C3N1C4=CC=C(Cl)C=C4

Molecular Formula

C20H13Cl2N3O2

Molecular Weight

398.24

References & Citations

[1]Kenneth Ewan, et al. A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 2010 Jul 15;70 (14) :5963-73.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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