JNJ-39729209

JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC50 of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448) -induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474) - and CFA (HY-153808) -induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs[1].

Product Specifications

CAS Number

[1160606-90-5]

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-39729209.html

Smiles

FC(C1=CC=C(NC2=C3C(SC(CC4=C(Cl)C=CC=C4Cl)=N3)=NC=N2)C=C1)(F)F

Molecular Formula

C19H11Cl2F3N4S

Molecular Weight

455.28

References & Citations

[1]Maher MP, et al., Characterization of 2- (2,6-dichloro-benzyl) -thiazolo[5,4-d]pyrimidin-7-yl]- (4-trifluoromethyl-phenyl) -amine (JNJ-39729209) as a novel TRPV1 antagonist. Eur J Pharmacol. 2011 Aug 1;663 (1-3) :40-50.