Sulfo-SMCC (sodium)
Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.
Product Specifications
CAS Number
[92921-24-9]
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
Biochemical Assay Reagents
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Sulfo-SMCC_sodium.html
Purity
99.92
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1CCC(CN2C(C=CC2=O)=O)CC1)ON3C(C(S(=O)(O[Na])=O)CC3=O)=O
Molecular Formula
C16H17N2NaO9S
Molecular Weight
436.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Prabhune M, et al. Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. PLoS One. 2016 Aug 25;11 (8) :e0161623.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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ASTM Method D6293 O-PONA Paraffin Mixture, 2 components: 3% each of n-Decane ; n-Nonane in n-Hexane / n-Heptane
