CDK2-IN-28

CDK2-IN-28 (compound 22) is a CDK2 inhibitor with good selectivity and cellular effects against other CDKs. CDK2-IN-28 has anti-proliferative effects on MKN1 cells (EC50: 0.31 μM) [1].

Product Specifications

CAS Number

[3025006-64-5]

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk2-in-28.html

Solubility

10 mM in DMSO

Smiles

CS(C1=CC=C(CN2)C(OCCCCCN(CC3CNC3)C4=NC5=C(C(C)C)C=NN5C2=N4)=C1)(=O)=O

Molecular Formula

C25H35N7O3S

Molecular Weight

513.66

References & Citations

[1]Niu P, et al. Discovery of novel macrocyclic derivatives as potent and selective cyclin-dependent kinase 2 inhibitors. Bioorg Med Chem. 2024 Apr 15;104:117711.