Pim-1 kinase inhibitor 8
Selected Variant
HY-162006-01
Size: 5 mg
Pim-1 kinase inhibitor 8 is a potent PIM-1 inhibitor with an IC50 value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC) -bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research[1].
Product Specifications
CAS Number
916038-47-6
UNSPSC
12352005
Target
Apoptosis; Autophagy; Pim
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pim-1-kinase-inhibitor-8.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=C(OCC(N2CCOCC2)=O)N=C(C)C=C1C
Molecular Formula
C14H17N3O3
Molecular Weight
275.30
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Price
Frequently Asked Questions
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