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Pim-1 kinase inhibitor 8

Pim-1 kinase inhibitor 8 is a potent PIM-1 inhibitor with an IC50 value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC) -bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; Pim

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pim-1-kinase-inhibitor-8.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N#CC1=C(OCC(N2CCOCC2)=O)N=C(C)C=C1C

Molecular Formula

C14H17N3O3

Molecular Weight

275.30

References & Citations

[1]Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8 (49) :46922-46933.|[2]Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8 (49) :46922-46933.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-162006/Pim-1-kinase-inhibitor-8-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-162006/Pim-1-kinase-inhibitor-8-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[916038-47-6]

Available Sizes

Curated Selection

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