Pim-1 kinase inhibitor 8

Pim-1 kinase inhibitor 8 is a potent PIM-1 inhibitor with an IC50 value of 14.3 nM. Pim-1 kinase inhibitor 8 impedes cell proliferation and migration through PIM-1 inhibition and the induction of both apoptosis and autophagy. Pim-1 kinase inhibitor 8 inhibits solid tumor growth in Solid Ehrlich Carcinoma (SEC) -bearing mice. Pim-1 kinase inhibitor 8 can be used for breast and liver cancer research[1].

Product Specifications

CAS Number

[916038-47-6]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Pim

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pim-1-kinase-inhibitor-8.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

N#CC1=C(OCC(N2CCOCC2)=O)N=C(C)C=C1C

Molecular Formula

C14H17N3O3

Molecular Weight

275.30

References & Citations

[1]Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8 (49) :46922-46933.|[2]Shaban SM, et al. Design and Synthesis of Novel Pyridine-Based Compounds as Potential PIM-1 Kinase Inhibitors, Apoptosis, and Autophagy Inducers Targeting MCF-7 Cell Lines: In Vitro and In Vivo Studies. ACS Omega. 2023 Nov 27;8 (49) :46922-46933.