α-Androstenol

α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50=0.4 μM) . α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice[1][2][3].

Product Specifications

CAS Number

[1153-51-1]

Product Name Alternative

5α-Androst-16-en-3α-ol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-androstenol.html

Purity

99.9

Solubility

DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@@]12CC=C[C@]1(CC[C@]3([C@]2(CC[C@]4(C[C@@H](CC[C@]34C)O)[H])[H])[H])C

Molecular Formula

C19H30O

Molecular Weight

274.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Brooksbank BW, et al. The detection of 5alpha-androst-16-en-3alpha-ol in human male axillary sweat. Experientia. 1974 Aug 15;30 (8) :864-5.|[2]Kaminski RM, et al. The pheromone androstenol (5 alpha-androst-16-en-3 alpha-ol) is a neurosteroid positive modulator of GABAA receptors. J Pharmacol Exp Ther. 2006 May;317 (2) :694-703. |[3]Starkenmann C, et al. 5α-Androst-16-en-3α-ol β-D-glucuronide, precursor of 5α-androst-16-en-3α-ol in human sweat. Chem Biodivers. 2013 Dec;10 (12) :2197-208.