Clindamycin Sulfoxide
Clindamycin sulfoxide is an active metabolite of the antibiotic Clindamycin (HY-B1455) . It is formed via S-oxidation of clindamycin primarily by the cytochrome P450 (CYP) isoform CYP3A4. Clindamycin sulfoxide inhibits the growth of P. prevotti, B. fragilis, and C. sordelli in vitro with MIC values of 2, 2, and 1 mg/L, respectively.
Product Specifications
CAS Number
[22431-46-5]
Product Name Alternative
U-25026A
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/clindamycin-sulfoxide.html
Smiles
O=C([C@H]1N(C[C@@H](C1)CCC)C)N[C@@]([H])([C@]2(O[C@@]([H])([C@@H]([C@H]([C@H]2O)O)O)S(C)=O)[H])[C@@H](Cl)C
Molecular Formula
C18H33ClN2O6S
Molecular Weight
440.98
Precautions
P264-P270-P330-P501
References & Citations
[1]Wynalda, et al. In vitro metabolism of clindamycin in human liver and intestinal microsomes. Drug Metab. Dispos. 31 (7), 878-887 (2003) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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