AMP-PCP (disodium)
AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1].
Product Specifications
CAS Number
[7414-56-4]
UNSPSC
12352005
Hazard Statement
H301+H311+H331, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amp-pcp-disodium.html
Purity
99.43
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O[C@H](COP(OP(CP(O)(O[Na])=O)(O[Na])=O)(O)=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2
Molecular Formula
C11H16N5Na2O12P3
Molecular Weight
549.17
Precautions
H301+H311+H331, H315, H319, H335
References & Citations
[1]Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90
Available Sizes
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