CGK733
CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.
Product Specifications
CAS Number
905973-89-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cgk733.html
Purity
99.83
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=S)C=C1[N+]([O-])=O
Molecular Formula
C23H18Cl3FN4O3S
Molecular Weight
555.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang H, et al. CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012 May 25;422 (1) :103-8.|[2]Alao JP, et al. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51.|[3]Williams TM, et al. Molecular imaging of the ATM kinase activity. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86 (5) :969-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM; ATR
Available Sizes
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