CGK733

CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.

Product Specifications

CAS Number

[905973-89-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cgk733.html

Purity

99.83

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC=C(NC(NC(C(Cl)(Cl)Cl)NC(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)=S)C=C1[N+]([O-])=O

Molecular Formula

C23H18Cl3FN4O3S

Molecular Weight

555.84

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang H, et al. CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012 May 25;422 (1) :103-8.|[2]Alao JP, et al. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51.|[3]Williams TM, et al. Molecular imaging of the ATM kinase activity. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86 (5) :969-77.